Yulia Dzhashiashivili, MD, PhD
Yulia's scientific interests are in the areas of neuron-glia interactions, myelination, myelin disorders, and neurodegeneration. Her postdoctoral fellowship project investigated the contribution of the unfolded protein response (UPR), a cytoprotective pathway activated in response to endoplasmic reticulum (ER) stress, to disease pathogenesis in mouse models of mutant SOD1-induced ALS. Yulia's current research is focused on elucidating the role of ER stress and the UPR in mouse models of multiple sclerosis (MS). There is strong evidence that ER stress and the UPR play an important role in MS. This study is a part of a larger effort to identify potential therapeutic pathways to protect oligodendrocytes, which are the principal target cells in MS, frequently dying during neuroinflammation and demyelination.